ParkinsonFranceV1, Main, Exploration, bibRecord, 000099

SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation

Identifieur interne : 000099 ( Main/Exploration ); précédent : 000098; suivant : 000100

SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation

Auteurs : Z. B. Wei ; Y. F. Yuan ; F. Jaouen [France] ; M. S. Ma ; C. J. Hao ; Z. Zhang ; Q. Chen ; Z. Yuan ; C. Beurrier [France] ; W. Li

Source :

Autophagy [ 1554-8627 ] ; 2016.

RBID : Hal:hal-01445052

English descriptors

mix :
- Parkinson disease, SLC35D3, autophagy, dopaminergic neuron, neurodegeneration, BECN1-ATG14-PIK3C3 complex.

Abstract

Searching for new regulators of autophagy involved in selective dopaminergic (DA) neuron loss is a hallmark in the pathogenesis of Parkinson disease (PD). We here report that an endoplasmic reticulum (ER)-associated transmembrane protein SLC35D3 is selectively expressed in subsets of midbrain DA neurons in about 10% TH (tyrosine hydroxylase)-positive neurons in the substantia nigra pars compacta (SNc) and in about 22% TH-positive neurons in the ventral tegmental area (VTA). Loss of SLC35D3 in ros (roswell mutant) mice showed a reduction of 11.9% DA neurons in the SNc and 15.5% DA neuron loss in the VTA with impaired autophagy. We determined that SLC35D3 enhanced the formation of the BECN1-ATG14-PIK3C3 complex to induce autophagy. These results suggest that SLC35D3 is a new regulator of tissue-specific autophagy and plays an important role in the increased autophagic activity required for the survival of subsets of DA neurons.

Url:

https://hal.archives-ouvertes.fr/hal-01445052

DOI: 10.1080/15548627.2016.1179402. Epub 2016 May 12.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000979
to stream Hal, to step Curation: 000979
to stream Hal, to step Checkpoint: 000089
to stream Main, to step Merge: 000100
to stream Main, to step Curation: 000099

Le document en format XML

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<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term> Parkinson disease</term>
<term> SLC35D3</term>
<term> autophagy</term>
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<front><div type="abstract" xml:lang="en">Searching for new regulators of autophagy involved in selective dopaminergic (DA) neuron loss is a hallmark in the pathogenesis of Parkinson disease (PD). We here report that an endoplasmic reticulum (ER)-associated transmembrane protein SLC35D3 is selectively expressed in subsets of midbrain DA neurons in about 10% TH (tyrosine hydroxylase)-positive neurons in the substantia nigra pars compacta (SNc) and in about 22% TH-positive neurons in the ventral tegmental area (VTA). Loss of SLC35D3 in ros (roswell mutant) mice showed a reduction of 11.9% DA neurons in the SNc and 15.5% DA neuron loss in the VTA with impaired autophagy. We determined that SLC35D3 enhanced the formation of the BECN1-ATG14-PIK3C3 complex to induce autophagy. These results suggest that SLC35D3 is a new regulator of tissue-specific autophagy and plays an important role in the increased autophagic activity required for the survival of subsets of DA neurons. </div>
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<name sortKey="Zhang, Z" sort="Zhang, Z" uniqKey="Zhang Z" first="Z." last="Zhang">Z. Zhang</name>
</noCountry>
<country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Jaouen, F" sort="Jaouen, F" uniqKey="Jaouen F" first="F." last="Jaouen">F. Jaouen</name>
</region>
<name sortKey="Beurrier, C" sort="Beurrier, C" uniqKey="Beurrier C" first="C." last="Beurrier">C. Beurrier</name>
</country>
</tree>
</affiliations>
</record>

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EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration

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{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Hal:hal-01445052
   |texte=   SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation

SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation

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Abstract

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